Reaction Details Report a problem with these data
Target
Actin [R183K]
Ligand
BDBM65516
Substrate
n/a
Meas. Tech.
Liquid growth assay
Temperature
303.1500±0.0000 K
IC50
11900±0.0 nM
Citation
 Filipuzzi, I; Thomas, JR; Pries, V; Estoppey, D; Salcius, M; Studer, C; Schirle, M; Hoepfner, D Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide. ACS Chem Biol 12:2264-2269 (2017) [PubMed]  Article 
Target
Name:
Actin [R183K]
Synonyms:
ACT1 (R183K) | Actin (R183K) | ACT_YEAST | ACT1 | ABY1 | END7
Type:
Protein
Mol. Mass.:
41655.11
Organism:
Baker's yeast
Description:
P60010 (R183K)
Residue:
375
Sequence:
MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGKDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF
  
Inhibitor
Name:
BDBM65516
Synonyms:
CHEBI:84382 | CHEMBL2426321 | Chondramide C
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: