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Target
cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941]
Ligand
BDBM14775
Substrate
BDBM10851
Meas. Tech.
Phosphodiesterase (PDE) Inhibition Assay
IC50
54000±n/a nM
Citation
 Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure 12:2233-47 (2004) [PubMed]  Article 
Target
Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941]
Synonyms:
PDE2A_HUMAN | PDE2A | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | cGMP-dependent 3,5-cyclic phosphodiesterase | cGSPDE | Phosphodiesterase Type 2 (PDE2A)
Type:
Enzyme
Mol. Mass.:
42724.46
Organism:
Human
Description:
Recombinant catalytic domain (H574-E941) of human PDE2A.
Residue:
368
Sequence:
HMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
  
Inhibitor
Name:
BDBM14775
Synonyms:
3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | Cpodpmb | CHEMBL42126 | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | RPR-73401 | Piclamilast
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2N2O3
Mol. Mass.:
380.07
SMILES:
COc1ccc(cc1OC2CCCC2)C(=O)Nc3c(cncc3Cl)Cl
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10851
Synonyms:
(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide | cid_23902375 | Cyclic adenosine monophosphate | (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | ADENOSINE-3 ,5 -CYCLIC-MONOPHOSPHATE | cAMP
Type:
Small organic molecule
Emp. Form.:
C10H12N5O6P
Mol. Mass.:
329.05
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
Structure:
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