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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM15131
Substrate
AKTide-2T
Meas. Tech.
PKB In Vitro Enzyme Assay
pH
7.2000±n/a
Temperature
295.1500±n/a K
IC50
0.5±n/a nM
Citation
 Davies, TG; Verdonk, ML; Graham, B; Saalau-Bethell, S; Hamlett, CC; McHardy, T; Collins, I; Garrett, MD; Workman, P; Woodhead, SJ; Jhoti, H; Barford, D A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. J Mol Biol 367:882-94 (2007) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
Serine/threonine-protein kinase AKT | RAC-PK-beta | Protein kinase Akt-2 | Protein kinase B beta (AKT2) | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | Protein kinase B, beta | PKB beta | Protein kinase B (Akt 2) | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase Rac alpha/beta | Serine/threonine-protein kinase AKT2 | AKT2_HUMAN | AKT2
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Human
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM15131
Synonyms:
5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-3-methyl-1H-indazole | 5-indazolyl pyridine 3 | indazole-pyridine, 4 | A-443654
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
AKTide-2T
Synonyms:
AKT/PKB/Rac Protein Kinase Substrate
Type:
Peptide
Mol. Mass.:
1719.90
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
ARKRERTYSFGHHA