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Target
Baculoviral IAP repeat-containing protein 2 [266-354]
Ligand
BDBM17344
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements.
pH
7.2000±n/a
Temperature
295.1500±n/a K
Ki
30±n/a nM
Citation
 Zobel, K; Wang, L; Varfolomeev, E; Franklin, MC; Elliott, LO; Wallweber, HJ; Okawa, DC; Flygare, JA; Vucic, D; Fairbrother, WJ; Deshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1:525-33 (2006) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [266-354]
Synonyms:
cIAP1XBIR3 | Chimeric protein of inhibitor of apoptosis protein 2-baculovirus IAP repeat 3 (BIR3) | cIAP1-BIR3/XIAP-BIR3 chimeric protein | BIRC2_HUMAN | BIRC2 | API1 | MIHB | RNF48 | cIAP1-BIR3
Type:
Chimeric Protein
Mol. Mass.:
10496.31
Organism:
Human
Description:
Q13490[266-354]
Residue:
89
Sequence:
MQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPH
  
Inhibitor
Name:
BDBM17344
Synonyms:
L-alanyl-L-valyl-L-prolyl-L-tryptophan | (2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid | AVPW
Type:
Polypeptide
Emp. Form.:
C24H33N5O5
Mol. Mass.:
471.25
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17342
Synonyms:
5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
Type:
Fluorescent dye-conjugated peptide
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: