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Target
Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ligand
BDBM18781
Substrate
BDBM18044
Meas. Tech.
Inhibitor Screening Using Bacterial System (IC50) and Measurement of Inhibition Constant (Ki)
Ki
6.59±n/a nM
IC50
30050±n/a nM
Citation
 Bunyarataphan, S; Leartsakulpanich, U; Taweechai, S; Tarnchompoo, B; Kamchonwongpaisan, S; Yuthavong, Y Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother 50:3631-7 (2006) [PubMed]  Article 
Target
Name:
Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Synonyms:
DRTS_PLAVI | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Muatnt (S58R/S117N) | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant SP21
Type:
Enzyme
Mol. Mass.:
27235.37
Organism:
malaria parasite P. vivax
Description:
O02604[1-238,S58R,S117N]
Residue:
238
Sequence:
MENLSDVFDIYAICACCKVAPTSEGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFRSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSNWESIPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESEFRVTSVSEVYNSKGTTLDFLVYSKV
  
Inhibitor
Name:
BDBM18781
Synonyms:
5-(4-bromophenyl)-6-ethylpyrimidine-2,4-diamine | CHEMBL282275 | P21
Type:
Small organic molecule
Emp. Form.:
C12H13BrN4
Mol. Mass.:
292.03
SMILES:
CCc1nc(N)nc(N)c1-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM18044
Synonyms:
(S)-2-{4-[(2-Amino-4-hydroxy-7,8-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | dihydrofolic acid
Type:
Small organic molecule
Emp. Form.:
C19H21N7O6
Mol. Mass.:
443.16
SMILES:
Nc1nc2c(c(=O)[nH]1)N=C(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2
Structure:
Search PDB for entries with ligand similarity: