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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM19185
Substrate
BDBM10990
Meas. Tech.
MAO Inhibition Assay
pH
7.4000±n/a
Temperature
310.1500±n/a K
IC50
29700±5700 nM
Citation
 Carotti, A; Catto, M; Leonetti, F; Campagna, F; Soto-Otero, R; Méndez-Alvarez, E; Thull, U; Testa, B; Altomare, C Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem 50:5364-71 (2007) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
Monoamine oxidase A (MAO-A) | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase type A (MAOA) | Amine oxidase [flavin-containing] A | Amine oxidase (flavin-containing) A | Monoamine oxidase A (rMAO-A) | AOFA_RAT | Maoa | Monoamine oxidase
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rat
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
  
Inhibitor
Name:
BDBM19185
Synonyms:
8,9,17-triazatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(10),2(7),3,5,8,11(16),12,14-octaene | Aza-heterocyclic Derivative, 6
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10990
Synonyms:
Diaminopropiophenone | 3-amino-1-(2-aminophenyl)propan-1-one | Kynuramine
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: