Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM19352
Substrate
BDBM18044
Meas. Tech.
DHFR Assay
pH
7.3000±n/a
Temperature
310.1500±n/a K
Comments
78% inhibition @ 1 uM
Citation
 Xin, Z; Serby, MD; Zhao, H; Kosogof, C; Szczepankiewicz, BG; Liu, M; Liu, B; Hutchins, CW; Sarris, KA; Hoff, ED; Falls, HD; Lin, CW; Ogiela, CA; Collins, CA; Brune, ME; Bush, EN; Droz, BA; Fey, TA; Knourek-Segel, VE; Shapiro, R; Jacobson, PB; Beno, DW; Turner, TM; Sham, HL; Liu, G Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists. J Med Chem 49:4459-69 (2006) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase | DYR_HUMAN | DHFR
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Human
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM19352
Synonyms:
6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-1,3-benzodiazol-5-yl}pyrimidine-2,4-diamine | 2,4-diaminopyrimidine-based antagonist, 7
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM18044
Synonyms:
(S)-2-{4-[(2-Amino-4-hydroxy-7,8-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | dihydrofolic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: