Target

Ligand

Substrate

Meas. Tech.

In Vitro Enzyme Assay

pH

6.1000±n/a

Temperature

310.1500±n/a K

Ki

5190±430 nM

Citation

 Inagaki, H; Tsuruoka, H; Hornsby, M; Lesley, SA; Spraggon, G; Ellman, JA Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. J Med Chem 50:2693-9 (2007) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Procathepsin L

Synonyms:

Cathepsin L1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein | CTSL CTSL1 | CATL1_HUMAN | CTSL | CTSL1

Type:

Enzyme

Mol. Mass.:

37557.19

Organism:

Human

Description:

Purchased from Calbiochem (San Diego, CA).

Residue:

333

Sequence:

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM19487

Synonyms:

2-[2-(2,3-difluoro-4-propylphenyl)phenoxy]acetaldehyde | Aldehyde Inhibitor, 12d

Type:

Small organic molecule

Emp. Form.:

C17H16F2O2

Mol. Mass.:

290.11

SMILES:

CCCc1ccc(c(F)c1F)-c1ccccc1OCC=O

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM19485

Synonyms:

Fluorogenic substrate | Z-Phe-Arg-AMC.HCl | Cbz-Phe-Arg-AMC

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: