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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM23570
Substrate
BDBM3158
Meas. Tech.
FabD/FabH Coupled Assay
pH
7.0000±n/a
Temperature
295.1500±n/a K
IC50
1600±n/a nM
Citation
 Nie, Z; Perretta, C; Lu, J; Su, Y; Margosiak, S; Gajiwala, KS; Cortez, J; Nikulin, V; Yager, KM; Appelt, K; Chu, S Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents. J Med Chem 48:1596-609 (2005) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
Beta-ketoacyl-ACP synthase III | 3-oxoacyl-[acyl-carrier-protein] synthase III | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | KAS III | FABH_ENTFA | fabH | beta-Ketoacyl-ACP Synthase III (FabH)
Type:
Acyltransferase; homodimer
Mol. Mass.:
35176.53
Organism:
Enterococcus faecalis (strain ATCC 700802 / V583)
Description:
The E. faecalis FabH was cloned, and protein was expressed in E. coli.
Residue:
321
Sequence:
MKNYARISCTSRYVPENCVTNHQLSEMMDTSDEWIHSRTGISERRIVTQENTSDLCHQVAKQLLEKSGKQASEIDFILVATVTPDFNMPSVACQVQGAIGATEAFAFDISAACSGFVYALSMAEKLVLSGRYQTGLVIGGETFSKMLDWTDRSTAVLFGDGAAGVLIEAAETPHFLNEKLQADGQRWAALTSGYTINESPFYQGHKQASKTLQMEGRSIFDFAIKDVSQNILSLVTDETVDYLLLHQANVRIIDKIARKTKISREKFLTNMDKYGNTSAASIPILLDEAVENGTLILGSQQRVVLTGFGGGLTWGSLLLTL
  
Inhibitor
Name:
BDBM23570
Synonyms:
2-{[4-bromo-3-(diethylsulfamoyl)benzene]amido}benzoic acid | Diethylsulfonamide Derivative, 13a
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM3158
Synonyms:
2-{[2,6-dihydroxy-4-({[(4S)-3-[(4-hydroxybenzene)amido]-1-azabicyclo[3.2.2]nonan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid | Balanol analog 24
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: