Reaction Details Report a problem with these data
Target
Aminopeptidase N
Ligand
BDBM23706
Substrate
BDBM23736
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
Citation
 Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed]  Article 
Target
Name:
Aminopeptidase N
Synonyms:
AP-M | CD_antigen=CD13 | Alanyl aminopeptidase | Aminopeptidase N (APN) | gp130 | pAPN | Microsomal aminopeptidase | AP-N | Aminopeptidase M | AMPN_PIG | ANPEP
Type:
Protein
Mol. Mass.:
108810.25
Organism:
Pig
Description:
P15145
Residue:
963
Sequence:
MAKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAEHVPQAPTSPTITTTAAITLDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
  
Inhibitor
Name:
BDBM23706
Synonyms:
1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrazole | N-Benzoylpyrazole deriv., 8
Type:
Small organic molecule
Emp. Form.:
C10H6Cl2N2O
Mol. Mass.:
239.99
SMILES:
Clc1ccc(cc1Cl)C(=O)n1cccn1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23736
Synonyms:
L-alanyl-p-nitroanilide
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: