Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM27782
Substrate
BDBM25143
Meas. Tech.
HDAC Activity Assay
pH
8.0000±n/a
Temperature
310.1500±n/a K
IC50
8±n/a nM
Citation
 Kattar, SD; Surdi, LM; Zabierek, A; Methot, JL; Middleton, RE; Hughes, B; Szewczak, AA; Dahlberg, WK; Kral, AM; Ozerova, N; Fleming, JC; Wang, H; Secrist, P; Harsch, A; Hamill, JE; Cruz, JC; Kenific, CM; Chenard, M; Miller, TA; Berk, SC; Tempest, P Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorg Med Chem Lett 19:1168-72 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | HDAC1_HUMAN | HDAC1 | RPD3L1 | Cereblon/Histone deacetylase 1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Human
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM27782
Synonyms:
N-(2-amino-5-phenylphenyl)-4-{1,8-diazaspiro[4.5]decan-8-ylcarbonyl}benzamide | terephthalamide, 30
Type:
Small organic molecule
Emp. Form.:
C28H30N4O2
Mol. Mass.:
454.24
SMILES:
Nc1ccc(cc1NC(=O)c1ccc(cc1)C(=O)N1CCC2(CCCN2)CC1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25143
Synonyms:
KI-104 (BioMol Research Laboratories) | Fluor-de-Lys Fluorogenic Deacetylase Substrate
Type:
Fluorogenic Substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: