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Target
Baculoviral IAP repeat-containing protein 2 [266-354]
Ligand
BDBM27919
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements
Ki
33±n/a nM
Citation
 Cohen, F; Alicke, B; Elliott, LO; Flygare, JA; Goncharov, T; Keteltas, SF; Franklin, MC; Frankovitz, S; Stephan, JP; Tsui, V; Vucic, D; Wong, H; Fairbrother, WJ Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem 52:1723-30 (2009) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [266-354]
Synonyms:
cIAP1XBIR3 | Chimeric protein of inhibitor of apoptosis protein 2-baculovirus IAP repeat 3 (BIR3) | cIAP1-BIR3/XIAP-BIR3 chimeric protein | BIRC2_HUMAN | BIRC2 | API1 | MIHB | RNF48 | cIAP1-BIR3
Type:
Chimeric Protein
Mol. Mass.:
10496.31
Organism:
Human
Description:
Q13490[266-354]
Residue:
89
Sequence:
MQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPH
  
Inhibitor
Name:
BDBM27919
Synonyms:
N-[(3aR,6S,6aS)-1-[(2S)-3,3-dimethyl-2-[(2S)-2-(methylamino)propanamido]butanoyl]-octahydrocyclopenta[b]pyrrol-6-yl]naphthalene-1-carboxamide | Azabicyclooctane scaffold, 14b
Type:
Small organic molecule
Emp. Form.:
C28H38N4O3
Mol. Mass.:
478.29
SMILES:
C[C@@H](C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1[C@H](CC2)NC(=O)c3cccc4c3cccc4)C(C)(C)C)NC
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17342
Synonyms:
5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
Type:
Fluorescent dye-conjugated peptide
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: