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Target
Caspase-8
Ligand
BDBM29574
Substrate
Caspase-8 Substrate
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4000±n/a
Temperature
310.1500±n/a K
IC50
>50000±n/a nM
Citation
 Chu, W; Rothfuss, J; Chu, Y; Zhou, D; Mach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem 52:2188-91 (2009) [PubMed]  Article 
Target
Name:
Caspase-8
Synonyms:
Caspase | Caspase-8 subunit p18 | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CASP-8 | Caspase-8 subunit p10 | MACH | FADD-homologous ICE/CED-3-like protease | FLICE | ICE-like apoptotic protease 5 | CAP4 | MORT1-associated CED-3 homolog | FADD-like ICE | CASP8_HUMAN | CASP8 | MCH5
Type:
Enzyme
Mol. Mass.:
55373.89
Organism:
Human
Description:
Q14790
Residue:
479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
  
Inhibitor
Name:
BDBM29574
Synonyms:
isatin Michael acceptor (IMA) analogue, 11c
Type:
Small organic molecule
Emp. Form.:
C23H6Cl2N4O3S
Mol. Mass.:
487.95
SMILES:
Clc1ccc(-[#6]-[#7]-2-[#6](=O)\[#6](=[#6](\C#N)C#N)-c3cc(ccc-23)S(=O)(=O)[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1Cl
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-8 Substrate
Synonyms:
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin
Type:
Fluorogenic Substrate
Mol. Mass.:
954.10
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
ACIETDAMC