Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM29569
Substrate
Caspase-3 Substrate
Meas. Tech.
Enzyme Inhibition Assay
IC50
>20000±n/a nM
Citation
 Chu, W; Rothfuss, J; Chu, Y; Zhou, D; Mach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem 52:2188-91 (2009) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
CPP-32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | Apopain | CASP-3 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein | CASP3_HUMAN | CASP3 | CPP32
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Human
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM29569
Synonyms:
isatin sulfonamide, 6 | acs.jmedchem.1c00409_ST.540
Type:
Small organic molecule
Emp. Form.:
C12H12N2O5S
Mol. Mass.:
296.05
SMILES:
O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-3 Substrate
Synonyms:
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
Type:
Fluorogenic Substrate
Mol. Mass.:
953.05
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
ACDEVDAMC