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Target
Caspase-7
Ligand
BDBM29569
Substrate
Caspase-7 Substrate
Meas. Tech.
Enzyme Inhibition Assay
IC50
>20000±n/a nM
Citation
 Chu, W; Rothfuss, J; Chu, Y; Zhou, D; Mach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem 52:2188-91 (2009) [PubMed]  Article 
Target
Name:
Caspase-7
Synonyms:
Caspase | caspase 7, apoptosis-related cysteine peptidase | CMH-1 | CASP-7 | Apoptotic protease Mch-3 | CASP7_HUMAN | CASP7 | MCH3
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Human
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM29569
Synonyms:
isatin sulfonamide, 6 | acs.jmedchem.1c00409_ST.540
Type:
Small organic molecule
Emp. Form.:
C12H12N2O5S
Mol. Mass.:
296.05
SMILES:
O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-7 Substrate
Synonyms:
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
Type:
Fluorogenic Substrate
Mol. Mass.:
953.05
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
ACDEVDAMC