Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM4779
Substrate
biotinylated affinity ligand
Meas. Tech.
Kinase Inhibitor Selectivity Profiling Assay
Kd
4200±n/a nM
Citation
 PubChem, PC Kinase Inhibitor Selectivity Profiling Assay PubChem Bioassay (2008)[AID] 
Target
Name:
Aurora kinase B
Synonyms:
Aurora kinase 2 | Aurora kinase B (AURKB) | AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B | AURKB_HUMAN | AURKB | AIK2 | AIM1 | AIRK2 | ARK2 | STK1 | STK12 | STK5
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Human
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM4779
Synonyms:
cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL31965 | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide | CI-1033 | US9730934, CI-1033 | Canertinib | US10507209, Compound CI-1033
Type:
Small organic molecule
Emp. Form.:
C24H25ClFN5O3
Mol. Mass.:
485.16
SMILES:
C=CC(=O)Nc1cc2c(cc1OCCCN3CCOCC3)ncnc2Nc4ccc(c(c4)Cl)F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
biotinylated affinity ligand
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA