Reaction Details Report a problem with these data
Target
Dimer of Gag-Pol polyprotein [489-587]
Ligand
BDBM714
Substrate
HIV-1 Protease substrate
Meas. Tech.
Protease Inhibition Assay
pH
6±n/a
Temperature
310.15±n/a K
Ki
5.14±n/a nM
Citation
 Mimoto, T; Kato, R; Takaku, H; Nojima, S; Terashima, K; Misawa, S; Fukazawa, T; Ueno, T; Sato, H; Shintani, M; Kiso, Y; Hayashi, H Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. J Med Chem 42:1789-802 (1999) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587]
Synonyms:
HIV-1 Protease
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10822.21
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10822.21
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM714
Synonyms:
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | (R)-N-tert-Butyl-3-[(2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzoyl)amino-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | JE-533
Type:
Small organic molecule
Emp. Form.:
C28H37N3O5S
Mol. Mass.:
527.675
SMILES:
Cc1c(O)cccc1C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV-1 Protease substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2535.82
Organism:
Synthetic peptide
Description:
n/a
Residue:
22
Sequence:
HSERGLNASNTYRPRILEVALH