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Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Ligand
BDBM31929
Substrate
BDBM8737
Meas. Tech.
Enzymatic Inhibition Assay
pH
8.0000±n/a
Temperature
298.1500±n/a K
Comments
72% inhibition @ 50 uM.
Citation
 He, L; Zhang, L; Liu, X; Li, X; Zheng, M; Li, H; Yu, K; Chen, K; Shen, X; Jiang, H; Liu, H Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J Med Chem 52:2465-81 (2009) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Synonyms:
(3R)-hydroxymyristoyl ACP dehydrase | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase | FABZ_HELPY | fabZ | beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)
Type:
Lyase
Mol. Mass.:
18198.05
Organism:
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
Description:
HpfabZ is expressed and purified from E. coli.
Residue:
159
Sequence:
MEQSHQNLQSQFFIEHILQILPHRYPMLLVDRIIELQANKKIVAYKNITFNEDVFNGHFPNKPIFPGVLIVEGMAQTGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLEYHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERD
  
Inhibitor
Name:
BDBM31929
Synonyms:
carbohydrazide derivative, 3l
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM8737
Synonyms:
trans-butyr-2-enoyl-CoA | But-2-enoyl-CoA | 2-Butenoyl-CoA | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-{[({[(3-{[2-({2-[(2E)-but-2-enoylsulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}-3-hydroxy-2,2-dimethylpropoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxy}phosphonic acid | Crotonoyl-CoA
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: