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Target
Baculoviral IAP repeat-containing protein 3
Ligand
BDBM32588
Substrate
Smac-derived peptide
Meas. Tech.
Fluorescence Polarization Assay
IC50
110±n/a nM
Citation
 Seneci, P; Bianchi, A; Battaglia, C; Belvisi, L; Bolognesi, M; Caprini, A; Cossu, F; Franco, E; Matteo, M; Delia, D; Drago, C; Khaled, A; Lecis, D; Manzoni, L; Marizzoni, M; Mastrangelo, E; Milani, M; Motto, I; Moroni, E; Potenza, D; Rizzo, V; Servida, F; Turlizzi, E; Varrone, M; Vasile, F; Scolastico, C Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy. Bioorg Med Chem 17:5834-56 (2009) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 3
Synonyms:
Baculoviral IAP repeat-containing protein 3 | Inhibitor of apoptosis protein 3 (cIAP2) | cIAP1/cIAP2 | BIRC3_HUMAN | BIRC3 | API2 | MIHC | RNF49 | Baculoviral IAP repeat-containing protein 3 (IAP1 BIR3) | XIAP-BIR3
Type:
Protein
Mol. Mass.:
68365.75
Organism:
Human
Description:
Q13489
Residue:
604
Sequence:
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
  
Inhibitor
Name:
BDBM32588
Synonyms:
1-aza-2-oxobicyclo[5.3.0]decane scaffold, 40a | 1-aza-2-oxobicyclo[5.3.0]decane scaffold, 18a
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Smac-derived peptide
Synonyms:
SM5F
Type:
fluorescently labelled peptide
Mol. Mass.:
1220.95
Organism:
n/a
Description:
5-carboxyfluorescein was coupled to the lysine side chain of the mutated Smac peptide.
Residue:
10
Sequence:
ARPFKFAMNH