Target
Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A,D531N]
Ligand
BDBM580
Substrate
Chromogenic peptide substrate
Meas. Tech.
Protease Inhibition Assay
pH
4.7±n/a
Temperature
310.15±n/a K
Ki
0.083±0.015 nM
Km
28000±3000 nM
kcat
17±2 1/sec
Citation
 Clemente, JCHemrajani, RBlum, LEGoodenow, MMDunn, BM Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N. Biochemistry 42:15029-35 (2003) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A,D531N]
Synonyms:
HIV-1 Protease Mutant (D30N)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A,D531N]
Synonyms:
HIV-1 Protease Mutant (D30N) chain A | HIV-1 Protease Mutant (D30N) chain B | LAI(D30N) | POL_HV1BR | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10732.13
Organism:
Human immunodeficiency virus type 1
Description:
P03367[501-599,Q508K,L534I,L564I,C568A,C596A,D531N]
Residue:
99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADNTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
  
Component 2
Name:
Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A,D531N]
Synonyms:
HIV-1 Protease Mutant (D30N) chain A | HIV-1 Protease Mutant (D30N) chain B | LAI(D30N) | POL_HV1BR | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10732.13
Organism:
Human immunodeficiency virus type 1
Description:
P03367[501-599,Q508K,L534I,L564I,C568A,C596A,D531N]
Residue:
99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADNTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
  
Inhibitor
Name:
BDBM580
Synonyms:
(4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide | AG1776 | BDBM50288366 | JE-2147 | KNI-764
Type:
Small organic molecule
Emp. Form.:
C32H37N3O5S
Mol. Mass.:
575.718
SMILES:
Cc1ccccc1CNC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(O)c1C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Chromogenic peptide substrate
Synonyms:
Chromogenic peptide substrate
Type:
Peptide
Mol. Mass.:
1420.11
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KARVLNPHEANLG