Reaction Details Report a problem with these data
Target
Coagulation factor XII
Ligand
BDBM33450
Substrate
Boc-Gln-Gly-Arg-AMC
Meas. Tech.
Factor XIIa Dose Response Confirmation from Single Well HTS
pH
7.4000±n/a
Temperature
296.1500±n/a K
IC50
8587.873333±n/a nM
Citation
 PubChem, PC Factor XIIa Dose Response Confirmation from Single Well HTS PubChem Bioassay (2007)[AID] 
Target
Name:
Coagulation factor XII
Synonyms:
Coagulation factor XIIa heavy chain | Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Coagulation factor XIIa light chain | Hageman factor | HAF | Factor XIIa (fXIIa) | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | FA12_HUMAN | F12 | Factor XIIa | Coagulation factor XII (FXII)
Type:
Enzyme
Mol. Mass.:
67810.07
Organism:
Human
Description:
P00748
Residue:
615
Sequence:
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
  
Inhibitor
Name:
BDBM33450
Synonyms:
cid_828591 | MLS000527908 | (5-Amino-3-furan-2-yl-[1,2,4]triazol-1-yl)-(4-chloro-phenyl)-methanone | [5-amino-3-(furan-2-yl)-1,2,4-triazol-1-yl]-(4-chlorophenyl)methanone | [5-amino-3-(2-furanyl)-1,2,4-triazol-1-yl]-(4-chlorophenyl)methanone | SMR000120482 | [5-azanyl-3-(furan-2-yl)-1,2,4-triazol-1-yl]-(4-chlorophenyl)methanone | [5-amino-3-(2-furyl)-1,2,4-triazol-1-yl]-(4-chlorophenyl)methanone
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Boc-Gln-Gly-Arg-AMC
Synonyms:
n/a
Type:
fluorescent substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA