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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM35654
Substrate
GSK-3 Substrate Peptide
Meas. Tech.
Ki Determination
Ki
110±n/a nM
Citation
Aronov, AM; Tang, Q; Martinez-Botella, G; Bemis, GW; Cao, J; Chen, G; Ewing, NP; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Markland, W; Namchuk, MN; Nanthakumar, S; Poondru, S; Straub, J; ter Haar, E; Xie, X Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J Med Chem 52:6362-8 (2009) [PubMed] Article
More Info.:
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Inhibitor
Name:
BDBM35654
Synonyms:
erk000526 | pyrimidylpyrrole, 11b
Type:
Small organic molecule
Emp. Form.:
C26H26ClN5O2
Mol. Mass.:
475.97
SMILES:
Cc1cccc(Nc2ncc(C)c(n2)-c2c[nH]c(c2)C(=O)N[C@H](CO)c2cccc(Cl)c2)c1C |r|
Substrate
Name:
GSK-3 Substrate Peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1641.04
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
HSSPHQSPHEDEEE