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Target
Cathepsin B
Ligand
BDBM36330
Substrate
BDBM36388
Meas. Tech.
Assay name: Protease Inhibition Assay
pH
5.5000±0.0000
Temperature
310.1500±0.0000 K
IC50
2.2e+2±n/a nM
Citation
 Kato, D; Boatright, KM; Berger, AB; Nazif, T; Blum, G; Ryan, C; Chehade, KA; Salvesen, GS; Bogyo, M Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1:33-8 (2005) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
CATB_RAT | Ctsb
Type:
Protein
Mol. Mass.:
37463.53
Organism:
Rat
Description:
P00787
Residue:
339
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
  
Inhibitor
Name:
BDBM36330
Synonyms:
AC-YFG-AMOK 10a
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
573.25
SMILES:
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Structure:
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Substrate
Name:
BDBM36388
Synonyms:
Octahydro-indolizine-1,6,7,8-tetraol, 13 | BDBM36404 | CID54445
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
189.10
SMILES:
O[C@H]1CCN2C[C@H](O)[C@@H](O)[C@H](O)[C@@H]12
Structure:
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