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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50115216
Substrate
n/a
Meas. Tech.
Serine/Threonine Kinase Inhibition Assay
Kd
197± 21 nM
Citation
 Simard, JR; Klüter, S; Grütter, C; Getlik, M; Rabiller, M; Rode, HB; Rauh, D A new screening assay for allosteric inhibitors of cSrc. Nat Chem Biol 5:394-6 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
MK14_HUMAN | MAPK14 | CSBP | CSBP1 | CSBP2 | CSPB1 | MXI2 | SAPK2A | CSAID-binding protein | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAX-interacting protein 2 | Mitogen-activated protein kinase p38 alpha | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Human
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50115216
Synonyms:
CHEMBL87580 | 1-[2-(3-Amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-phenyl-urea | 1-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)-3-phenylurea | 1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)-3-phenylurea, 1b | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(C)c1cc(NC(=O)Nc2ccccc2)n(n1)-c1cccc(N)c1
Structure:
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