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Target
Aminodeoxyfutalosine nucleosidase
Ligand
BDBM22113
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5000±0.0000
Temperature
298.1500±0.0000 K
Kd
0.571±0.0 nM
Citation
 Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed]  Article 
Target
Name:
Aminodeoxyfutalosine nucleosidase
Synonyms:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | MTN | Methylthioadenosine Nucleosidase (MTAN) | 6-amino-6-deoxyfutalosine N-ribosylhydrolase
Type:
Enzyme
Mol. Mass.:
25200.22
Organism:
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
Description:
O24915
Residue:
231
Sequence:
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
  
Inhibitor
Name:
BDBM22113
Synonyms:
DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(9-Deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine, 7 | MT-DADMe-ImmA
Type:
n/a
Emp. Form.:
C13H19N5OS
Mol. Mass.:
293.13
SMILES:
CSC[C@H]1C[N@](C[C@@H]1O)Cc2c[nH]c3c2ncnc3N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | CHEMBL277041 | 5-methylthioadenosine | 5'-Methylthioado | (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H15N5O3S
Mol. Mass.:
297.09
SMILES:
CSC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
Structure:
Search PDB for entries with ligand similarity: