Reaction Details Report a problem with these data
Target
Aminodeoxyfutalosine nucleosidase
Ligand
BDBM36435
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5000±0.0000
Temperature
298.1500±0.0000 K
Kd
0.515±0.0 nM
Citation
 Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed]  Article 
Target
Name:
Aminodeoxyfutalosine nucleosidase
Synonyms:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | MTN | Methylthioadenosine Nucleosidase (MTAN) | 6-amino-6-deoxyfutalosine N-ribosylhydrolase
Type:
Enzyme
Mol. Mass.:
25200.22
Organism:
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
Description:
O24915
Residue:
231
Sequence:
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
  
Inhibitor
Name:
BDBM36435
Synonyms:
DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthio-methyl-3-hydroxypyrrolidine, 8
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | CHEMBL277041 | 5-methylthioadenosine | 5'-Methylthioado | (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: