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Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM36435
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5000±0.0000
Temperature
298.1500±0.0000 K
Kd
1.3±0.0 nM
Citation
 Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | MTNN_STAAC | mtnN | Methylthioadenosine Nucleosidase (MTAN)
Type:
Enzyme
Mol. Mass.:
24526.81
Organism:
Staphylococcus aureus (Firmicutes)
Description:
Q5HFG2
Residue:
228
Sequence:
MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTLLINKFKPDVIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQSSKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQTCYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL
  
Inhibitor
Name:
BDBM36435
Synonyms:
DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthio-methyl-3-hydroxypyrrolidine, 8
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | CHEMBL277041 | 5-methylthioadenosine | 5'-Methylthioado | (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H15N5O3S
Mol. Mass.:
297.09
SMILES:
CSC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
Structure:
Search PDB for entries with ligand similarity: