Reaction Details Report a problem with these data
Target
Dimer of Retinoic acid receptor RXR-alpha
Ligand
BDBM50032675
Substrate
n/a
Meas. Tech.
Ligand Binding Assay
pH
7.4000±0.0000
Temperature
277.1500±0.0000 K
Kd
18±5 nM
Citation
 Peet, DJ; Doyle, DF; Corey, DR; Mangelsdorf, DJ Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. Chem Biol 5:13-21 (1998) [PubMed]  Article 
Target
Name:
Dimer of Retinoic acid receptor RXR-alpha
Synonyms:
Retinoid X receptor alpha (F313I/L436F) | Retinoid X receptor alpha (F313I/L436V)
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nuclear receptor subfamily 2 group B member 1 | Retinoid X receptor alpha | Retinoid receptor | Nuclear receptor subfamily 4 group A member 2 | RXRA_HUMAN | RXRA | NR2B1 | Retinoic acid receptor RXR-alpha/gamma | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Human
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Component 2
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nuclear receptor subfamily 2 group B member 1 | Retinoid X receptor alpha | Retinoid receptor | Nuclear receptor subfamily 4 group A member 2 | RXRA_HUMAN | RXRA | NR2B1 | Retinoic acid receptor RXR-alpha/gamma | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Human
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50032675
Synonyms:
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid | CHEMBL1023 | p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid | BEXAROTENE
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cc2c(cc1C(=C)c3ccc(cc3)C(=O)O)C(CCC2(C)C)(C)C
Structure:
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