Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43262
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
2528±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
Rac1 protein | RAC1_MOUSE | Rac1
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mouse
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43262
Synonyms:
1-[5-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-2,4-dimethyl-1H-pyrrol-3-yl]ethanone | 1-[5-[3,4-dihydro-1H-isoquinolin-2-yl(oxo)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]ethanone | MLS000045229 | SMR000026821 | cid_3238851 | 1-[5-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-2,4-dimethyl-1H-pyrrol-3-yl]ethanone | 1-[5-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-2,4-dimethyl-1H-pyrrol-3-yl]ethanone
Type:
Small organic molecule
Emp. Form.:
C18H20N2O2
Mol. Mass.:
296.15
SMILES:
CC(=O)c1c(C)[nH]c(C(=O)N2CCc3ccccc3C2)c1C
Structure:
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