Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43278
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
635.2±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
Rac1 protein | RAC1_MOUSE | Rac1
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mouse
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43278
Synonyms:
cid_22332901 | 1-[2-(5-methyl-2-propan-2-yl-phenoxy)ethyl]indole-3-carboxylic acid | UNM000011077301 | 1-[2-(5-methyl-2-propan-2-ylphenoxy)ethyl]-3-indolecarboxylic acid | 1-[2-(5-methyl-2-propan-2-ylphenoxy)ethyl]indole-3-carboxylic acid | 1-[2-(2-isopropyl-5-methyl-phenoxy)ethyl]indole-3-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C21H23NO3
Mol. Mass.:
337.17
SMILES:
CC(C)c1ccc(C)cc1OCCn1cc(C(O)=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: