Reaction Details
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GTPase KRas [1-37]
Ligand
BDBM54691
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant
EC50
30000±n/a nM
Comments
Extracted from aid = 2043 and tid = 2
Citation
PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay (2009)[AID] More Info.:
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Human
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
Inhibitor
Name:
BDBM54691
Synonyms:
2-azanyl-5-(phenylcarbonyl)-4-(3,4,5-trimethoxyphenyl)-1-[2,4,6-tri(propan-2-yl)phenyl]sulfonyl-pyrrole-3-carbonitrile | 2-amino-5-benzoyl-4-(3,4,5-trimethoxyphenyl)-1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylpyrrole-3-carbonitrile | UNM-0000305781 | cid_25220932 | 2-amino-5-benzoyl-4-(3,4,5-trimethoxyphenyl)-1-[2,4,6-tri(propan-2-yl)phenyl]sulfonyl-3-pyrrolecarbonitrile | 2-amino-5-benzoyl-1-(2,4,6-triisopropylphenyl)sulfonyl-4-(3,4,5-trimethoxyphenyl)pyrrole-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
