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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50019848
Substrate
n/a
Ki
3±n/a nM
Comments
PDSP_959
Citation
 Hieble, JP; DeMarinis, RM; Fowler, PJ; Matthews, WD Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity. J Pharmacol Exp Ther 236:90-6 (1986) [PubMed] 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
Alpha-2A adrenergic receptor | ADA2A_CAVPO | ADRA2A | adrenergic Alpha2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48933.12
Organism:
Guinea pig
Description:
adrenergic Alpha2 0 GUINEA PIG::Q60474
Residue:
450
Sequence:
MGSLQPDSGNASWNGTEGPGGGTRATPYSLQVTVTLVCLVGLLILLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKAGGGGQQPAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAHAAAPPGGAERRPNGLGLERGVGPGGAEAEPLPTQVNGAPGEPAPAGPRDAEALDLEESSSSEHAERPPGARRPERGLRAKSKARASQVKPGDSLPRRAPGAAGSGTSGSGPGEERGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50019848
Synonyms:
CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole | 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C1CN=C(N1)C1COc2ccccc2O1 |c:2|
Structure:
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