Reaction Details Report a problem with these data
Target
Carbonic anhydrase 3
Ligand
BDBM50210256
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5000±0.0000
Temperature
293.1500±0.0000 K
Ki
7.8E5±0.0 nM
Citation
 De Simone, G; Scozzafava, A; Supuran, CT Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? Chem Biol Drug Des 74:317-21 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 3
Synonyms:
Carbonic anhydrase 3 (CA III) | CA-III | Carbonate dehydratase III | Carbonic anhydrase III (CA III) | CAH3_HUMAN | CA3 | Carbonic anhydrase | Carbonic Anhydrase III
Type:
Enzyme
Mol. Mass.:
29562.11
Organism:
Human
Description:
Human cloned isozyme.
Residue:
260
Sequence:
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK
  
Inhibitor
Name:
BDBM50210256
Synonyms:
CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-3a-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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