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Target
Cyclin-dependent kinase 5
Ligand
BDBM84532
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5000±0.0000
Temperature
303.1500±0.0000 K
IC50
250±0.0 nM
Citation
 Kunick, C; Zeng, Z; Gussio, R; Zaharevitz, D; Leost, M; Totzke, F; Schächtele, C; Kubbutat, MH; Meijer, L; Lemcke, T Structure-aided optimization of kinase inhibitors derived from alsterpaullone. Chembiochem 6:541-9 (2005) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
Cyclin-dependent-like kinase 5 (CDK5) | Cell division protein kinase 5 | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | Cyclin-dependent-like kinase 5 | CDK5_HUMAN | CDK5 | CDKN5 | PSSALRE
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Human
Description:
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM84532
Synonyms:
Alsterpaullone derivative, 6
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COC(=O)CCc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)[N+]([O-])=O)-c2c1
Structure:
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