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Target
Acidic mammalian chitinase
Ligand
BDBM50243795
Substrate
n/a
Meas. Tech.
ChEMBL_1672910 (CHEMBL4022939)
IC50
3.5±n/a nM
Citation
 Mazur, M; Olczak, J; Olejniczak, S; Koralewski, R; Czestkowski, W; Jedrzejczak, A; Golab, J; Dzwonek, K; Dymek, B; Sklepkiewicz, PL; Zagozdzon, A; Noonan, T; Mahboubi, K; Conway, B; Sheeler, R; Beckett, P; Hungerford, WM; Podjarny, A; Mitschler, A; Cousido-Siah, A; Fadel, F; Golebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem 61:695-710 (2018) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50243795
Synonyms:
CHEMBL4077644
Type:
Small organic molecule
Emp. Form.:
C22H26Cl2N6
Mol. Mass.:
445.388
SMILES:
Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1Cl
Structure:
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