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Target
Chitotriosidase-1
Ligand
BDBM50243760
Substrate
n/a
Meas. Tech.
ChEMBL_1672912 (CHEMBL4022941)
IC50
123±n/a nM
Citation
 Mazur, M; Olczak, J; Olejniczak, S; Koralewski, R; Czestkowski, W; Jedrzejczak, A; Golab, J; Dzwonek, K; Dymek, B; Sklepkiewicz, PL; Zagozdzon, A; Noonan, T; Mahboubi, K; Conway, B; Sheeler, R; Beckett, P; Hungerford, WM; Podjarny, A; Mitschler, A; Cousido-Siah, A; Fadel, F; Golebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem 61:695-710 (2018) [PubMed]  Article 
Target
Name:
Chitotriosidase-1
Synonyms:
Chitotriosidase | Chitinase-1 | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) | CHIT1_HUMAN | CHIT1 | Chitinase 1
Type:
Enzyme
Mol. Mass.:
51682.25
Organism:
Human
Description:
Q13231
Residue:
466
Sequence:
MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
  
Inhibitor
Name:
BDBM50243760
Synonyms:
CHEMBL4082060
Type:
Small organic molecule
Emp. Form.:
C22H33ClN6
Mol. Mass.:
416.25
SMILES:
Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)CC1CCCCC1
Structure:
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