Target
Acidic mammalian chitinase
Ligand
BDBM50243685
Substrate
n/a
Meas. Tech.
ChEMBL_1672911 (CHEMBL4022940)
IC50
6.2±n/a nM
Citation
 Mazur, MOlczak, JOlejniczak, SKoralewski, RCzestkowski, WJedrzejczak, AGolab, JDzwonek, KDymek, BSklepkiewicz, PLZagozdzon, ANoonan, TMahboubi, KConway, BSheeler, RBeckett, PHungerford, WMPodjarny, AMitschler, ACousido-Siah, AFadel, FGolebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem 61:695-710 (2018) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | CHIA_MOUSE | Chia | Chia1 | YNL
Type:
PROTEIN
Mol. Mass.:
51991.60
Organism:
Mus musculus
Description:
ChEMBL_828636
Residue:
473
Sequence:
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
  
Inhibitor
Name:
BDBM50243685
Synonyms:
CHEMBL4084573
Type:
Small organic molecule
Emp. Form.:
C26H29ClN6
Mol. Mass.:
461.002
SMILES:
Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: