Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50003738
Substrate
n/a
Meas. Tech.
ChEMBL_208714 (CHEMBL808495)
KOFF
0.00022 s-1
Citation
 Rai, R; Katzenellenbogen, JA Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases. J Med Chem 35:4297-305 (1992) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
THRB_HUMAN | F2 | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | Prothrombin precursor | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Human
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50003738
Synonyms:
CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-oxo-tetrahydro-pyran-3-yl)-benzyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NC(=N)NCc1ccc(cc1)C1CC\C(OC1=O)=C\I
Structure:
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