Target
Dual specificity protein kinase CLK1
Ligand
BDBM50259589
Substrate
n/a
Meas. Tech.
ChEBML_1691310
IC50
23±n/a nM
Citation
 Bendjeddou, LZLoaëc, NVilliers, BPrina, ESpäth, GFGalons, HMeijer, LOumata, N Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. Eur J Med Chem 125:696-709 (2017) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty
Type:
PROTEIN
Mol. Mass.:
57124.52
Organism:
Mouse
Description:
ChEMBL_1502245
Residue:
483
Sequence:
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT
  
Inhibitor
Name:
BDBM50259589
Synonyms:
CHEMBL4065432
Type:
Small organic molecule
Emp. Form.:
C17H19N5O2
Mol. Mass.:
325.3651
SMILES:
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(\C=N\O)c3)n2n1 |r|
Structure:
Search PDB for entries with ligand similarity: