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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50010062
Substrate
n/a
Meas. Tech.
ChEMBL_31457 (CHEMBL643939)
IC50
25±n/a nM
Citation
 Wrobel, J; Millen, J; Sredy, J; Dietrich, A; Gorham, BJ; Malamas, M; Kelly, JM; Bauman, JG; Harrison, MC; Jones, LR Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives. J Med Chem 34:2504-20 (1991) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
ALDR_BOVIN | AKR1B1 | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bovine
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50010062
Synonyms:
CHEMBL84152 | [(2-Fluoro-6-methoxy-5-trifluoromethyl-naphthalene-1-carbonyl)-methoxycarbonyl-amino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COC(=O)N(CC(O)=O)C(=O)c1c(F)ccc2c(c(OC)ccc12)C(F)(F)F
Structure:
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