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Target
Pancreatic alpha-amylase
Ligand
BDBM50222205
Substrate
n/a
Meas. Tech.
ChEBML_1696961
IC50
31200±n/a nM
Citation
 Zhang, BW; Xing, Y; Wen, C; Yu, XX; Sun, WL; Xiu, ZL; Dong, YS Pentacyclic triterpenes asα-glucosidase andα-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. Bioorg Med Chem Lett 27:5065-5070 (2017) [PubMed]  Article 
Target
Name:
Pancreatic alpha-amylase
Synonyms:
1,4-alpha-D-glucan glucanohydrolase | PA | AMYP_PIG | AMY2
Type:
Protein
Mol. Mass.:
57088.07
Organism:
Pig
Description:
P00690
Residue:
511
Sequence:
MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQPFANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM50222205
Synonyms:
(1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | 2alpha,2beta-dihydroxy-18beta-ursan-12-ene-28-oic acid | Corosolic acid | 2alpha,3beta-Dihydroxyurs-12-en-28-oic Acid | 2-alpha-hydroxyursolic acid | CHEMBL391533 | US11660306, Example Corosolic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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