Target
Cyclin-O/Cyclin-dependent kinase 2
Ligand
BDBM50263013
Substrate
n/a
Meas. Tech.
ChEBML_1697431
IC50
138±n/a nM
Citation
 Bharate, SBKumar, VJain, SKMintoo, MJGuru, SKNuthakki, VKSharma, MBharate, SSGandhi, SGMondhe, DMBhushan, SVishwakarma, RA Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J Med Chem 61:1664-1687 (2018) [PubMed]  Article 
Target
Name:
Cyclin-O/Cyclin-dependent kinase 2
Synonyms:
CDK2/Cyclin O
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1697431
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-O
Synonyms:
CCNO | CCNO_HUMAN | CDK2/Cyclin O | Cyclin-O
Type:
PROTEIN
Mol. Mass.:
38106.14
Organism:
Homo sapiens
Description:
ChEMBL_117722
Residue:
350
Sequence:
MVTPCPTSPSSPAARAGRRDNDQNLRAPVKKSRRPRLRRKQPLHPLNPCPLPGDSGICDLFESPSSGSDGAESPSAARGGSPLPGPAQPVAQLDLQTFRDYGQSCYAFRKAQESHFHPREALARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFLTTTPVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFTLGAPTISFFLEHFTHARVEAGQAEASEALEAQALARGVAELSLADYAFTSYSPSLLAICCLALADRMLRVSRPVDLRLGDHPEAALEDCMGKLQLLVAINSTSLTHMLPVQICEKCSLPPSSK
  
Inhibitor
Name:
BDBM50263013
Synonyms:
CHEMBL4079206
Type:
Small organic molecule
Emp. Form.:
C23H21Cl2NO5
Mol. Mass.:
462.323
SMILES:
CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(Cl)cccc1Cl)cc2=O |r|
Structure:
Search PDB for entries with ligand similarity: