Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50267124
Substrate
n/a
Meas. Tech.
ChEMBL_1702178 (CHEMBL4053411)
Kd
1.6±n/a nM
Citation
 Schwehm, C; Kellam, B; Garces, AE; Hill, SJ; Kindon, ND; Bradshaw, TD; Li, J; Macdonald, SJ; Rowedder, JE; Stoddart, LA; Stocks, MJ Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinaseδ (PI3Kδ) Inhibitors. J Med Chem 60:1534-1554 (2017) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
CCR-5 | C-C CKR-5 | CC-CKR-5 | CHEMR13 | CCR5/mu opioid receptor complex | HIV-1 fusion coreceptor | CD_antigen=CD195 | CCR5_HUMAN | CCR5 | CMKBR5 | C-C chemokine receptor type 5
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Human
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50267124
Synonyms:
CHEMBL2163486
Type:
Small organic molecule
Emp. Form.:
C29H41F2N5O
Mol. Mass.:
513.68
SMILES:
Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
Structure:
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