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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50268143
Substrate
n/a
Meas. Tech.
ChEMBL_1704484 (CHEMBL4055717)
Ki
5000±n/a nM
Citation
 Špaček, P; Keough, DT; Chavchich, M; Dračínský, M; Janeba, Z; Naesens, L; Edstein, MD; Guddat, LW; Hocková, D Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs. Bioorg Med Chem 25:4008-4030 (2017) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | HPRT_HUMAN | HPRT1 | HPRT
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Human
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50268143
Synonyms:
CHEMBL4090584
Type:
Small organic molecule
Emp. Form.:
C13H18N4Na4O9P2
Mol. Mass.:
528.21
SMILES:
Nc1nc2n(ccc2c(=O)[nH]1)C(COCCP([O-])([O-])=O)COCCP([O-])([O-])=O
Structure:
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