Reaction Details Report a problem with these data
Target
Delta(24)-sterol reductase
Ligand
BDBM20186
Substrate
n/a
Meas. Tech.
ChEBML_1719393
IC50
0.700000±n/a nM
Citation
 Müller, C; Hemmers, S; Bartl, N; Plodek, A; Körner, A; Mirakaj, V; Giera, M; Bracher, F New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem 140:305-320 (2017) [PubMed]  Article 
Target
Name:
Delta(24)-sterol reductase
Synonyms:
1.3.1.72 | 24-dehydrocholesterol reductase | 3-beta-hydroxysterol Delta-24-reductase | Delta(24)-sterol reductase | Diminuto/dwarf1 homolog | Seladin-1 | DHC24_HUMAN | DHCR24 | KIAA0018 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase
Type:
PROTEIN
Mol. Mass.:
60115.66
Organism:
Human
Description:
ChEMBL_117046
Residue:
516
Sequence:
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
  
Inhibitor
Name:
BDBM20186
Synonyms:
(4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]-N,N-dimethylpentanamide | cholenic acid dimethylamide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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