Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM50405257
Substrate
n/a
Meas. Tech.
ChEMBL_1738572 (CHEMBL4154322)
IC50
3330±n/a nM
Citation
 Crespo, I; Giménez-Dejoz, J; Porté, S; Cousido-Siah, A; Mitschler, A; Podjarny, A; Pratsinis, H; Kletsas, D; Parés, X; Ruiz, FX; Metwally, K; Farrés, J Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. Eur J Med Chem 152:160-174 (2018) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
Aldo-keto reductase family 1 member B10 | Small intestine reductase | ARL-1 | hARP | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldose reductase-related protein | SI reductase | Aldose reductase-like | ARP | AK1BA_HUMAN | AKR1B10 | AKR1B11 | Aldo-keto reductase family member 1B10 (AKR1B10)
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Human
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM50405257
Synonyms:
CHEMBL4174434
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O3
Mol. Mass.:
407.86
SMILES:
CCCc1nc2c(nc3ccccc3c2c(=O)n1CC(O)=O)-c1ccc(Cl)cc1
Structure:
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