Reaction Details Report a problem with these data
Target
Folate receptor beta
Ligand
BDBM50457435
Substrate
n/a
Meas. Tech.
ChEMBL_1759623 (CHEMBL4194631)
IC50
0.580000±n/a nM
Citation
 Ravindra, M; Wallace-Povirk, A; Karim, MA; Wilson, MR; O'Connor, C; White, K; Kushner, J; Polin, L; George, C; Hou, Z; Matherly, LH; Gangjee, A Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. J Med Chem 61:2027-2040 (2018) [PubMed]  Article 
Target
Name:
Folate receptor beta
Synonyms:
FBP | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein | FOLR2_HUMAN | FOLR2
Type:
PROTEIN
Mol. Mass.:
29286.32
Organism:
Human
Description:
ChEMBL_20077
Residue:
255
Sequence:
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
  
Inhibitor
Name:
BDBM50457435
Synonyms:
CHEMBL4214638
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: