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Target
Retinoic acid receptor alpha
Ligand
BDBM50457542
Substrate
n/a
Meas. Tech.
ChEMBL_1760056 (CHEMBL4195064)
EC50
11±n/a nM
Citation
 Thoreau, E; Arlabosse, JM; Bouix-Peter, C; Chambon, S; Chantalat, L; Daver, S; Dumais, L; Duvert, G; Feret, A; Ouvry, G; Pascau, J; Raffin, C; Rodeville, N; Soulet, C; Tabet, S; Talano, S; Portal, T Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. Bioorg Med Chem Lett 28:1736-1741 (2018) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50457542
Synonyms:
CHEMBL4212472
Type:
Small organic molecule
Emp. Form.:
C19H17NO2S
Mol. Mass.:
323.409
SMILES:
CC1(C)CCSc2ccc(cc12)C#Cc1cccc(n1)C(O)=O
Structure:
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