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Target
Bromodomain-containing protein 3
Ligand
BDBM50092312
Substrate
n/a
Meas. Tech.
ChEMBL_1767166 (CHEMBL4219278)
IC50
39±n/a nM
Citation
 Zhou, B; Hu, J; Xu, F; Chen, Z; Bai, L; Fernandez-Salas, E; Lin, M; Liu, L; Yang, CY; Zhao, Y; McEachern, D; Przybranowski, S; Wen, B; Sun, D; Wang, S Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem 61:462-481 (2018) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 3
Synonyms:
Bromodomain-containing protein 3 | RING3-like protein | Bromodomain-containing protein 3 (BRD3) | BRD3_HUMAN | BRD3 | KIAA0043 | RING3L | Bromodomain and extra-terminal motif (BET)
Type:
Protein
Mol. Mass.:
79571.81
Organism:
Human
Description:
Q15059
Residue:
726
Sequence:
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
  
Inhibitor
Name:
BDBM50092312
Synonyms:
Birabresib | MK-8628 | OTX-015
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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