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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM15581
Substrate
n/a
Meas. Tech.
ChEBML_1769486
IC50
2.7±n/a nM
Citation
 Xu, R; Xiao, G; Li, Y; Liu, H; Song, Q; Zhang, X; Yang, Z; Zheng, Y; Tan, Z; Deng, Y Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorg Med Chem 26:1885-1895 (2018) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
MAO-A | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) | Amine oxidase (flavin-containing) A | AOFA_HUMAN | MAOA
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Human
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM15581
Synonyms:
US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine | CHEMBL8706 | CLG | CLORGILINE | N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine | Clorgyline | US9603833, Clorgyline
Type:
Small organic molecule
Emp. Form.:
C13H15Cl2NO
Mol. Mass.:
271.05
SMILES:
C[N@](CCCOc1ccc(cc1Cl)Cl)CC#C
Structure:
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